- Analgesic (relieves pain)
- Anti-hyperlipidemic (reduces lipid levels in the blood)
- Anti-inflammatory (oral and topical)
- Anti-tumor (skin cancer)
- Anti-ulcer
- Antiangiogenesis (the starvation of cancer cells)
- Antibacterial
- Antifungal
- Antimicrobial
- Antioxidant
- Antiviral
- COX-2 inhibitor (non-steroidal anti-inflammatory drug)
- Diuretic (promotes the production of urine)
- Hepatoprotective (prevents damage to the liver)
- Improves hair (forms oil-resistant barriers)
- Improves skin (forms oil-resistant barriers)
- Induces skeletal muscle hypertrophy
- Inhibits TPA-induced initiation (Topical application)
- Inhibits the growth of Candida albicans and Microsporium lenosum
- Prevents and improves age spots
- Prevents and improves wrinkles
- Reduces adiposity (fat)
- Restores skin collagen bundle structures and its elasticity
- Bilberry
- Cherry laurel leaves
- Devil's Claw
- Elder Flowers (European Variety)
- Hawthorn
- Holy Basil
- Lavender
- Oregano
- Peppermint leaves
- Periwinkle
- Sage (greatest concentration of extractable ursolic acid)
- Thyme
Foods Containing Ursolic Acid:
- apples
- bilberries
- cranberries
- prunes
Ursolic acid & Cosmetic Products:
- relatively non-toxic in topical applications
- found in many cosmetic products (anti-aging creams)
- Hair tonics
Ursolic acid & Pharmacological Uses:
- Relatively non-toxic in internal applications
- Used as a preventative for various ailments including neoplastic tumors
- Used in ointments to treat burns.
Disclaimer:
Any information provided on www.answersoutlined.blogspot.com is for informational purposes only. The information provided is not provided as medical advice. Information in this article is not exhaustive, does not cover all conditions, and does not provide treatment for disease or illness. Information can become outdated when new scientific discoveries are made. Seek the advice of your physician before undertaking any diet, exercise, supplement, or medical program.
References:
De Tommasi, N., De Simone, F., and Pizza, C. (1992) constituents of Eriobotrya japonica. A study of their antiviral properties. J. Nat. Prod. 55 (8), 1067-1073.
Granger, S. and Scott, I. (1998) Skin care compositions containing a polycyclic triterpene carboxylic acid and a retenol. Unites States Patent no. 5,723, 139.
Harry, R.G. (1963) Cosmetic Materials. Their Origin, Characteristics, Uses, and Dermatological Action. Chemical Publishing Co., Inc., New York, NY.
Hirota, M., Mori, T., Yoshida, M., Iriye, R. (1990) Suppression of tumor promoter-induced inflammation of mouse ear by ursolic acid and 4,4-dimethylcholestane derivatives. Agric. Biol. Chem. 54(4), 1073-1075.
Huang, M., Ho, C., Wang, z., Ferraro, T., Lou, Y., Stauber, K., Ma, W., Georgiadis, C., Laskin, J., and Conney, A. (1994) Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 54, 701-708.
Ishida, M., Okubo, T., Koshimizu, K., Daito, H., Tokuda, H., Kin, T., Yamamoto, T., and Yamazaki, N. (1990) Topical preparations containing ursolic acid and/ or oleanolic acid for prevention of skin cancer. Chemical Abstract 113, 12173y.
Katsuo, M., Hiroki, T., Norio, F., Yasutomo, N., and Yukiko, Y. (1997) Photoaging inhibitor and dermal agent for external use. Japanese patent publication No. 09143050.
Kikuko, T., Shigemi, S., Masahiro, S., and Tatsu, M. (1993) Hair-raising cosmetic. Japanese Patent, no. 05286835.
Kowalewski, Z., Kortus, M., Ediza, W.; and Koniar, H. (1976) Antibiotic action of beta-ursolic acid. Arch. Immunol. Ther. Exp. (Warsz) 24 (1), 115-119.
Leung, A.Y. and Foster, s. (1996) 2nd edition encyclopedia of common Natural Ingredients Used in Food, Drugs, and Cosmetics. John Wiley and Sons Inc. New York, NY.
Liu, J. (1995) Pharmacology of oleanolic and ursolic acid. J. Ethnopharmacology 49, 57-68.
Muto, Y., Ninomiya, M., and Fujiki, H. (1990) Present status research on cancer chemoprevention in Japan. Japanese J. of Clinical Oncology 20, 219-224.
Ncbi.nlm.nih.gov. "Pharmacology of oleanolic acid and ursolic ... [J Ethnopharmacol. 1995] - PubMed - NCBI." 1995. Web. 19 Apr 2013. <http://www.ncbi.nlm.nih.gov/pubmed/8847885>.
Okazaki, T., Suetsugu, M.; and Yoshida, T. (1987) Hair tonics containing oleanolic derivatives. Chemical Abstracts 107, P161369V.
Reico, M.C, Giner, R., Terencio, M., Sanz, M., and Rios, J. (1991) Anti-inflammatory activity of Helichrysum stoechas. Planta Medica 57(2), A56-A57.
Sattar, a., Bankova, V., Kujumgiev, a., Galabov, A., Ignatova, A., Todorova, C., and Popov, S. (1995) Chemical composition and biological activity of leaf exudates from some Lamiaceae plants. Pharmazie 50, 62-65.
Tokuda, H., Ohigashi, H., Koshimizu, K., and Ito, Y. (1986) Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Letters 33, 279-285.
Ursolicacid.com. "BOTANICAL SOURCES." 2000. Web. 18 Apr 2013. <http://www.ursolicacid.com/botanical.htm>.
Ursolicacid.com. "TOXICITY." 2000. Web. 18 Apr 2013. <http://www.ursolicacid.com/toxicity.htm>.
Zaletova, N., Shchavlinskii, A., Tolkachev, O., Vichkanova, S., Fateeva, T., Krutikova, N.; Yartseva, I., and Klyuev, N. (1987) Preparation of some derivatives of ursolic acid and their antimicrobial activity. Chemical Abstracts 106, 18867e.
Harry, R.G. (1963) Cosmetic Materials. Their Origin, Characteristics, Uses, and Dermatological Action. Chemical Publishing Co., Inc., New York, NY.
Hirota, M., Mori, T., Yoshida, M., Iriye, R. (1990) Suppression of tumor promoter-induced inflammation of mouse ear by ursolic acid and 4,4-dimethylcholestane derivatives. Agric. Biol. Chem. 54(4), 1073-1075.
Huang, M., Ho, C., Wang, z., Ferraro, T., Lou, Y., Stauber, K., Ma, W., Georgiadis, C., Laskin, J., and Conney, A. (1994) Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 54, 701-708.
Ishida, M., Okubo, T., Koshimizu, K., Daito, H., Tokuda, H., Kin, T., Yamamoto, T., and Yamazaki, N. (1990) Topical preparations containing ursolic acid and/ or oleanolic acid for prevention of skin cancer. Chemical Abstract 113, 12173y.
Katsuo, M., Hiroki, T., Norio, F., Yasutomo, N., and Yukiko, Y. (1997) Photoaging inhibitor and dermal agent for external use. Japanese patent publication No. 09143050.
Kikuko, T., Shigemi, S., Masahiro, S., and Tatsu, M. (1993) Hair-raising cosmetic. Japanese Patent, no. 05286835.
Kowalewski, Z., Kortus, M., Ediza, W.; and Koniar, H. (1976) Antibiotic action of beta-ursolic acid. Arch. Immunol. Ther. Exp. (Warsz) 24 (1), 115-119.
Leung, A.Y. and Foster, s. (1996) 2nd edition encyclopedia of common Natural Ingredients Used in Food, Drugs, and Cosmetics. John Wiley and Sons Inc. New York, NY.
Liu, J. (1995) Pharmacology of oleanolic and ursolic acid. J. Ethnopharmacology 49, 57-68.
Muto, Y., Ninomiya, M., and Fujiki, H. (1990) Present status research on cancer chemoprevention in Japan. Japanese J. of Clinical Oncology 20, 219-224.
Ncbi.nlm.nih.gov. "Pharmacology of oleanolic acid and ursolic ... [J Ethnopharmacol. 1995] - PubMed - NCBI." 1995. Web. 19 Apr 2013. <http://www.ncbi.nlm.nih.gov/pubmed/8847885>.
Okazaki, T., Suetsugu, M.; and Yoshida, T. (1987) Hair tonics containing oleanolic derivatives. Chemical Abstracts 107, P161369V.
Reico, M.C, Giner, R., Terencio, M., Sanz, M., and Rios, J. (1991) Anti-inflammatory activity of Helichrysum stoechas. Planta Medica 57(2), A56-A57.
Sattar, a., Bankova, V., Kujumgiev, a., Galabov, A., Ignatova, A., Todorova, C., and Popov, S. (1995) Chemical composition and biological activity of leaf exudates from some Lamiaceae plants. Pharmazie 50, 62-65.
Tokuda, H., Ohigashi, H., Koshimizu, K., and Ito, Y. (1986) Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Letters 33, 279-285.
Ursolicacid.com. "BOTANICAL SOURCES." 2000. Web. 18 Apr 2013. <http://www.ursolicacid.com/botanical.htm>.
Ursolicacid.com. "TOXICITY." 2000. Web. 18 Apr 2013. <http://www.ursolicacid.com/toxicity.htm>.
Zaletova, N., Shchavlinskii, A., Tolkachev, O., Vichkanova, S., Fateeva, T., Krutikova, N.; Yartseva, I., and Klyuev, N. (1987) Preparation of some derivatives of ursolic acid and their antimicrobial activity. Chemical Abstracts 106, 18867e.
